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M9480529.TXT
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1994-08-20
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Document 0529
DOCN M9480529
TI Intestinal mucosal immunoglobulins during human immunodeficiency virus
type 1 infection.
DT 9410
AU Janoff EN; Jackson S; Wahl SM; Thomas K; Peterman JH; Smith PD;
Department of Medicine, VA Medical Center, Minneapolis, MN 55417.
SO J Infect Dis. 1994 Aug;170(2):299-307. Unique Identifier : AIDSLINE
MED/94308593
AB In intestinal fluid samples from 39 human immunodeficiency virus type 1
(HIV-1)-infected patients, IgA and IgG levels were equivalent, whereas
in 10 controls, IgA levels were significantly higher than those of IgG
(P < .05). Intestinal IgA in patients contained predominantly monomeric
IgA1, whereas IgA1 and IgA2 subclass levels in controls were nearly
equivalent and primarily polymeric. The predominance of IgG and
monomeric IgA1 in mucosal fluid samples from HIV-1-infected patients
suggests exudation of serum immunoglobulins into the intestine. The
decreased proportion of mucosal plasma cells producing IgA and IgA2 in
the HIV-1-infected patients (P < .01) may also contribute to the
abnormal intestinal immunoglobulin levels. Intestinal IgG reacted with
most HIV-1 antigens, whereas specific IgA was present in only 10 of 17
patients and reacted with only envelope (gp120 and gp160) and, less
often, core (p17 and p24) antigens. Aberrant mucosal antibody responses
and decreased integrity of the mucosal barrier may contribute to the
intestinal dysfunction and infections that characterize HIV-1 infection.
DE Diarrhea/*COMPLICATIONS/IMMUNOLOGY Duodenum/IMMUNOLOGY Human HIV
Antibodies/ANALYSIS HIV Infections/COMPLICATIONS/*IMMUNOLOGY
HIV-1/*IMMUNOLOGY IgA/BLOOD IgA, Secretory/ANALYSIS
IgG/ANALYSIS/BLOOD IgM/ANALYSIS/BLOOD Immunoglobulins/*ANALYSIS/BLOOD
Intestinal Mucosa/*IMMUNOLOGY Plasma Cells/IMMUNOLOGY Support,
Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't,
P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).